Additional Cannabinoids

Learn about the 100+ cannabinoids and the ‘entourage effect’

What we know about cannabinoids

Research into the many lesser known cannabinoids in cannabis is continuing globally. Below is an outline of what we currently know:

THC (Tetrahydrocannabinol)

Potential effects 1,2
Analgesic, anti-Inflammatory, reduced spasm, antiemetic, sleep, intoxication, neuroprotective, appetite stimulation

CBD (Cannabidiol)

Potential effects 1,2
Analgesic, anti-Inflammatory, anti-convulsive, antiemetic, sleep, reduces the intoxicating effect of THC, anti-anxiety, anti-depressant, neuroprotective, appetite stimulation, improved cognition

THCA* (Tetrahydrocannabinolic acid)

Potential effects 1,2
Anti-inflammatory, antiemetic, reduced spasm- non-intoxicating (seizure), appetite stimulation, sleep, neuroprotective

CBDA (Cannabidiolic acid)

Potential effects 1,2
Anti-inflammatory, antiemetic, reduces spasm

CBG (Cannabigerol)

Potential effects 1,2
Analgesic, anti-spasticity, anti-anxiety

CBC (Cannabichromene)

Potential effects 1,2
Anti-inflammatory, analgesic, anti-anxiety, anti-depressant

CBN (Cannabinol)

Potential effects 1,2
Anti-convulsive, analgesic, sleep, anti-inflammatory

THCV (Tetrahydrocannnabivarin)

Potential effects 1,2
Appetite suppressant, aids memory,anti-anxiety

The 'entourage effect'

The ‘entourage effect’, proposes whole plant cannabis extract made up of hundreds of active ingredients, including terpenes, flavanoids and cannabinoids, is more effective than isolated cannabinoids or terpenes used individually to treat a condition.

Investigations have shown whole plant extracts (with single cannabinoid dominance) are up to four times more effective than isolated single cannabinoids.

Research is on-going into the synergistic potential of whole plant extract in a variety of conditions, but generally whole plant extract is preferred.

References

1. Ahmed SA., et al. ‘Minor oxygenated cannabinoids from high potency Cannabis sativa L’, Phytochemistry , vol. 117, 2015, pp. 194-199.

2. Russo, EB, ‘Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects’, British Journal of Pharmacology, vol. 163, 2011, pp. 1344-1364.

3. Russo, E and Guy, GW., ‘A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol’, Medical Hypotheses, vol. 66, 2006, pp. 234-246.

The Endocannabinoid system

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THC & CBD

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