THC & CBD

The two most researched cannabinoids

THC & CBD explained


The Cannabis plant contains up to 545 chemical compounds including 114 different cannabinoids which may interact with the body’s cannabinoid receptors.

The best studied and most abundant cannabinoids are Δ 9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

THC is a cannabinoid that has been shown to help patients treat chronic pain, inflammation, spasticity, and nausea. It also has intoxicating effects.

CBD is a non-intoxicating cannabinoid typically prescribed for seizures, pain, anxiety and inflammation. CBD is non-addictive and less potent than THC with very low toxicity.

THC and CBD may work synergistically, while CBD also antagonises the adverse side effects associated with THC.

Cannabis formulations have different ratios of THC to CBD. Each formulation:

  • Provides different therapeutic effects.
  • Interacts differently with each person’s endocannabinoid system and biochemistry.
  • Can have a different side effect profile in patients.

References

Abramovici, H., ‘Information for Health Care Professionals: Cannabis (marihuana, marijuana) and the cannabinoids’, Health Canada, 2013, https://www. canada.ca/en/health-canada/services/drugs-medication/cannabis/information-medical-practitioners/information-health-care-professionals-cannabis-cannabinoids.html (accessed 17 January 2019).

Ahmed SA., et al. ‘Minor oxygenated cannabinoids from high potency Cannabis sativa L’, Phytochemistry , vol. 117, 2015, pp. 194-199.

Russo, EB, ‘Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects’, British Journal of Pharmacology, vol. 163, 2011, pp. 1344-1364.

The Endocannabinoid system

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Additional Cannabinoids

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